Scientists successfully transfer longevity gene and extend lifespan

 

Naked mole rats are not much to look at, but their biology has made them one of the most fascinating animals in aging research. These small, wrinkled rodents can live for decades, rarely develop cancer, and seem unusually protected from many of the diseases that normally arrive with age.

Researchers at the University of Rochester showed that one of those biological advantages can be moved into another mammal. By transferring a gene linked to the naked mole rat's unusually high levels of high molecular weight hyaluronic acid (HMW-HA), the team improved health and modestly extended lifespan in mice.

The work, published in Nature in 2023, suggested that at least some longevity traits that evolved in long-lived animals may be adaptable beyond the species that developed them. The genetically modified mice lived healthier lives and had an approximate 4.4 percent increase in median lifespan compared with ordinary mice.

"Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals," says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester.

Gorbunova, along with Andrei Seluanov, a professor of biology, and their colleagues, focused on a gene that helps produce HMW-HA. This substance is abundant in naked mole rats and has been tied to their striking resistance to cancer, inflammation, and age-related decline.

Why Naked Mole Rats Fascinate Aging Scientists

Naked mole rats are about the size of mice, yet their lifespans are extraordinary for rodents. They can live up to 41 years, nearly ten times longer than similarly sized rodents.

Their long lives are not the only reason scientists study them. As they age, naked mole rats appear to avoid many conditions that commonly affect other mammals, including neurodegeneration, cardiovascular disease, arthritis, and cancer. For decades, Gorbunova, Seluanov, and other researchers have been investigating how these animals stay so resilient.

One major clue is HMW-HA. Naked mole rats carry roughly ten times more of it than mice and humans. In earlier work, researchers found that when HMW-HA was removed from naked mole rat cells, those cells became more likely to form tumors.

That finding raised a powerful question. If HMW-HA helps naked mole rats resist cancer and age-related damage, could the same mechanism work in a different animal?

Transferring a Naked Mole Rat Longevity Gene

To test the idea, the Rochester team engineered mice to carry the naked mole rat version of the hyaluronan synthase 2 gene. This gene helps make the protein that produces HMW-HA.

All mammals have a version of hyaluronan synthase 2, but the naked mole rat version appears to be especially active. It seems to drive stronger gene expression, leading to greater production of the protective molecule.

The modified mice developed higher levels of hyaluronan in several tissues. They also showed stronger protection against spontaneous tumors and chemically induced skin cancer.

The effects were not limited to cancer resistance. The mice carrying the naked mole rat gene stayed healthier overall, lived longer than regular mice, had less inflammation in multiple tissues as they aged, and maintained better gut health.

Because chronic inflammation is one of the major biological features of aging, the reduction in inflammation was especially important. The researchers believe HMW-HA may work partly by directly influencing the immune system, although more research is needed to explain exactly how it produces such broad benefits.

A Small Lifespan Gain With Big Implications

The increase in median lifespan was about 4.4 percent, which is modest. But the larger significance is that a longevity mechanism from one mammal was successfully transferred to another.

That makes the finding more than a mouse study about a single gene. It supports the idea that nature's long-lived species may contain biological tools that can be studied, adapted, and possibly used to improve health in other animals.

"It took us 10 years from the discovery of HMW-HA in the naked mole rat to showing that HMW-HA improves health in mice," Gorbunova says. "Our next goal is to transfer this benefit to humans."

The researchers believe there may be two main ways to pursue that goal. One would be to slow the breakdown of HMW-HA in the body. Another would be to increase its production.

"We already have identified molecules that slow down hyaluronan degradation and are testing them in pre-clinical trials," Seluanov says. "We hope that our findings will provide the first, but not the last, example of how longevity adaptations from a long-lived species can be adapted to benefit human longevity and health."

Newer Research Adds to the Naked Mole Rat Story

Since the 2023 Nature study, naked mole rats have continued to offer new clues about why they age so differently from other mammals. A 2025 study in Science reported another potential longevity mechanism involving cGAS, a protein better known for its role in immune defense. In humans and mice, cGAS can interfere with some forms of DNA repair, but the naked mole rat version appears to help cells repair DNA damage more effectively. That study found that specific changes in the naked mole rat protein improved genome stability and delayed signs of aging in experimental models.

This newer work does not replace the HMW-HA finding. Instead, it strengthens a broader pattern. Naked mole rats likely owe their unusually long, healthy lives to several overlapping defenses, including cancer resistance, inflammation control, DNA repair, and tissue protection.

For human aging research, that matters. A single molecule is unlikely to become a simple fountain of youth. But each discovery gives scientists another possible route for targeting the biological processes that drive age-related disease.

The 2023 gene transfer study remains a striking proof of concept. A survival strategy that evolved in one of nature's strangest mammals helped mice resist disease, age more smoothly, and live longer. The next challenge is determining whether those same biological tricks can be safely adapted to improve human healthspan.

Journal Reference:

1. Zhihui Zhang, Xiao Tian, J. Yuyang Lu, Kathryn Boit, Julia Ablaeva, Frances Tolibzoda Zakusilo, Stephan Emmrich, Denis Firsanov, Elena Rydkina, Seyed Ali Biashad, Quan Lu, Alexander Tyshkovskiy, Vadim N. Gladyshev, Steve Horvath, Andrei Seluanov, Vera Gorbunova. Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice. Nature, 2023; 621 (7977): 196 DOI: 10.1038/s41586-023-06463-0

Courtesy:

University of Rochester. "Scientists successfully transfer longevity gene and extend lifespan." ScienceDaily. ScienceDaily, 10 May 2026. <www.sciencedaily.com/releases/2026/05/260510030948.htm>. 

 

 

 

 

A rare cancer-fighting plant compound has been decoded

 

Researchers at UBC Okanagan have uncovered the process plants use to create mitraphylline, a rare natural compound that has attracted attention for its possible cancer fighting properties.

Mitraphylline belongs to a unique class of plant chemicals known as spirooxindole alkaloids. These molecules are recognized for their unusual twisted ring structures and their powerful biological effects, including anti inflammatory and anti tumor activity.

Even though scientists have studied these compounds for years, the exact molecular steps plants use to produce them had remained unknown.

Breakthrough Discovery in Plant Chemistry

That mystery began to unravel in 2023 when Dr. Thu-Thuy Dang's team in UBC Okanagan's Irving K. Barber Faculty of Science identified the first known plant enzyme capable of twisting a molecule into the distinctive spiro shape.

Building on that earlier finding, doctoral student Tuan-Anh Nguyen led new research that uncovered two critical enzymes involved in the production of mitraphylline. One enzyme organizes the molecule into the correct three dimensional structure, while the second transforms it into mitraphylline itself.

"This is similar to finding the missing links in an assembly line," says Dr. Dang, UBC Okanagan Principal's Research Chair in Natural Products Biotechnology. "It answers a long-standing question about how nature builds these complex molecules and gives us a new way to replicate that process."

Why Mitraphylline Is So Valuable

Many promising natural compounds are found only in tiny amounts inside plants, making them difficult and expensive to recreate in laboratories. Mitraphylline is one of those rare substances. It exists only in trace quantities in tropical trees such as Mitragyna (kratom) and Uncaria (cat's claw), both members of the coffee family.

Now that researchers have identified the enzymes responsible for shaping and assembling mitraphylline, they have a clearer path toward producing the compound and related molecules in more sustainable ways.

"With this discovery, we have a green chemistry approach to accessing compounds with enormous pharmaceutical value," says Nguyen. "This is a result of UBC Okanagan's research environment, where students and faculty work closely to solve problems with global reach."

Nguyen also reflected on the experience of contributing to the breakthrough.

"Being part of the team that uncovered the enzymes behind spirooxindole compounds has been amazing," Nguyen adds. "UBC Okanagan's mentorship and support made this possible, and I'm excited to keep growing as a researcher here in Canada."

International Collaboration Fuels the Research

The project brought together Dr. Dang's laboratory at UBC Okanagan and Dr. Satya Nadakuduti's research group at the University of Florida.

Funding for the work came from Canada's Natural Sciences and Engineering Research Council's Alliance International Collaboration program, the Canada Foundation for Innovation, and the Michael Smith Health Research BC Scholar Program. Additional support was provided by the United States Department of Agriculture's National Institute of Food and Agriculture.

"We are proud of this discovery coming from UBC Okanagan. Plants are fantastic natural chemists," Dr. Dang says. "Our next steps will focus on adapting their molecular tools to create a wider range of therapeutic compounds."

Journal Reference:

1. Larissa C Laforest, Tuan-Anh M Nguyen, Gabriel Oliveira Matsumoto, Pavithra Ramachandria, Andre Chanderbali, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R McCurdy, Thu-Thuy T Dang, Satya Swathi Nadakuduti. A chromosome-level Mitragyna parvifolia genome unveils spirooxindole alkaloid diversification and mitraphylline biosynthesis. The Plant Cell, 2025; 37 (9) DOI: 10.1093/plcell/koaf207

Courtesy:

University of British Columbia Okanagan. "A rare cancer-fighting plant compound has been decoded." ScienceDaily. ScienceDaily, 12 May 2026. <www.sciencedaily.com/releases/2026/05/260512213836.htm>.