New study of MRSA spread provides framework for community-based infection surveillance

The identification of the recent spread of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in a Brooklyn religious enclave is helping medical experts better understand how certain high-risk populations can drive the evolution of antimicrobial resistance and identify steps that can be taken to curtail its spread, according to a new study.

Publishing Monday, January 7, 2019, in the journal PNAS (Proceedings of the National Academy of Sciences), a team of researchers led by NYU School of Medicine noted that, in 2016, they began to see a growing number of CA-MRSA related skin infections in infants and young children from Brooklyn's Orthodox Jewish communities. A preliminary investigation showed that a unique strain of CA-MRSA was spreading -- similar to what would happen in a hospital outbreak.

Their findings also suggested transmission was occurring via the gastrointestinal tract -- and, perhaps even more alarmingly, that this specific strain of CA-MRSA accumulated genes that both increased virulence and conferred resistance to the two most common topical treatments used for decolonization and infection prevention: mupiricin and chlorhexidine. The resulting strains and consequential DNA elements potentially threaten larger human populations, including vulnerable populations in hospitals.

Because of the study team's initial surveillance and rapid response, the outbreak in Brooklyn is well characterized. They further conclude that the use of genomic surveillance, which helped identify this bacterial cluster and which continues to enhance infection-control methods in hospital settings, should be applied more vigilantly to community-based pathogen surveillance.

"Our experience in Brooklyn suggests that hospital-based genomic surveillance data can be applied to bridge the divide between hospital and community epidemiology, and therefore make it easier to identify and respond to community-based disease clusters," says Bo Shopsin, MD, PhD, The Saul J. Farber Assistant Professor of Medicine at NYU School of Medicine, NYU Langone Health's Director of Epidemiology, and senior author on the study. "Follow-up infection control strategies could help prevent further spread of antimicrobial-resistant pathogens such as CA-MRSA."

Journal Reference:

1. Richard Copin, William E. Sause, Yi Fulmer, Divya Balasubramanian, Sophie Dyzenhaus, Jamil M. Ahmed, Krishan Kumar, John Lees, Anna Stachel, Jason C. Fisher, Karl Drlica, Michael Phillips, Jeffrey N. Weiser, Paul J. Planet, Anne-Catrin Uhlemann, Deena R. Altman, Robert Sebra, Harm van Bakel, Jennifer Lighter, Victor J. Torres, Bo Shopsin. Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus. Proceedings of the National Academy of Sciences, 2019; 201814265 DOI: 10.1073/pnas.1814265116.

Courtesy: ScienceDaily