The MRSA staphylococcus is an example of a pathogen, the likes
of which are often called superbugs. These are resistant to most
antibiotics and can cause serious infections.
"In the case of MRSA, these bacteria have also spread in
hospitals almost world-wide," says Jukka Corander, professor at the
University of Helsinki, who was a member of the international research
team that mapped several millennia of the evolution of the staphylococcus.
In their extensive study, the researchers sequenced whole genomes of the superbugs from a large sample from different animals as well as humans, and were able to study the DNA changes that helped the bacteria to adapt to new host organisms during thousands of years.
First, there were humans
Based on genome analysis, humans were most probably the original hosts to these superbugs, and judging from DNA changes, the ability to colonise domestic animals appeared in an age when the first animals were domesticated to become livestock on farms.
In the study, published recently in Nature Ecology & Evolution, the team discovered that cows are still the source for such strains of staphylococcus that are causing MRSA infections in humans around the world.
"Our observations give emphasis to the importance of detailed epidemiological monitoring, so that strains with the potential to cause epidemics can be discovered as early as possible," Jukka Corander says.
Detailed genomic analyses reveal that, when the bacteria move from one host species to another, it hijacks new genes to help it adapt and stay alive in the long term. In some cases, these genes give the bacteria resistance towards commonly used antibiotics, eventually rendering them so-called superbugs.
The research may promote the development of strategies to minimize the risk of new strains transferring into the human population, and help slow down the occurrence and spreading of resistance to antibiotics.
In their extensive study, the researchers sequenced whole genomes of the superbugs from a large sample from different animals as well as humans, and were able to study the DNA changes that helped the bacteria to adapt to new host organisms during thousands of years.
First, there were humans
Based on genome analysis, humans were most probably the original hosts to these superbugs, and judging from DNA changes, the ability to colonise domestic animals appeared in an age when the first animals were domesticated to become livestock on farms.
In the study, published recently in Nature Ecology & Evolution, the team discovered that cows are still the source for such strains of staphylococcus that are causing MRSA infections in humans around the world.
"Our observations give emphasis to the importance of detailed epidemiological monitoring, so that strains with the potential to cause epidemics can be discovered as early as possible," Jukka Corander says.
Detailed genomic analyses reveal that, when the bacteria move from one host species to another, it hijacks new genes to help it adapt and stay alive in the long term. In some cases, these genes give the bacteria resistance towards commonly used antibiotics, eventually rendering them so-called superbugs.
The research may promote the development of strategies to minimize the risk of new strains transferring into the human population, and help slow down the occurrence and spreading of resistance to antibiotics.
Journal Reference:
- Emily J. Richardson, Rodrigo Bacigalupe, Ewan M. Harrison, Lucy A. Weinert, Samantha Lycett, Manouk Vrieling, Kirsty Robb, Paul A. Hoskisson, Matthew T. G. Holden, Edward J. Feil, Gavin K. Paterson, Steven Y. C. Tong, Adebayo Shittu, Willem van Wamel, David M. Aanensen, Julian Parkhill, Sharon J. Peacock, Jukka Corander, Mark Holmes, J. Ross Fitzgerald. Gene exchange drives the ecological success of a multi-host bacterial pathogen. Nature Ecology & Evolution, 2018; 2 (9): 1468 DOI: 10.1038/s41559-018-0617-0
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